L’acide hyaluronique en dentisterie : études cliniques considérables


The effect of hyaluronan on bone and soft tissue and immune response in wound healing. Engström PE, Shi XQ, Tronje G, Larsson A, Welander U, Frithiof L, Engstrom GN. – J Periodontol. 2001 Sep;72(9):1192-200.

Treatment of gingivitis with hyaluronan. Jentsch H, Pomowski R, Kundt G, Göcke R. – J Clin Periodontol. 2003 Feb;30(2):159-64.

The clinical application of hyaluronic acid in gingivitis therapy. Pistorius A, Martin M, Willershausen B, Rockmann P. – Quintessence Int. 2005 Jul-Aug;36(7-8):531-8.

Evaluation of the efficacy of an hyaluronic acid-based biogel on periodontal clinical parameters. A randomized-controlled clinical pilot study. Pilloni A, Annibali S, Dominici F, Di Paolo C, Papa M, Cassini MA, Polimeni A. – Ann Stomatol (Roma). 2011 Mar;2(3-4):3-9. Epub 2012 Jan 27.

Effect of hyaluronan on periodontitis: A clinical and histological study. Gontiya G, Galgali SR. – J Indian Soc Periodontol. 2012 Apr;16(2):184-92. doi: 10.4103/0972-124X.99260

Hyaluronic Acid as an adjunct after scaling and root planing: a prospective randomized clinical trial. Eick S, Renatus A, Heinicke M, Pfister W, Stratul SI, Jentsch H. – J Periodontol. 2013 Jul;84(7):941-9. doi: 10.1902/jop.2012.120269. Epub 2012 Oct 22.

Effectiveness of adjunctive subgingival administration of amino acids and sodium hyaluronate gel on clinical and immunological parameters in the treatment of chronic periodontitis. Bevilacqua L, Eriani J, Serroni I, Liani G, Borelli V, Castronovo G, Di Lenarda R. – Ann Stomatol (Roma). 2012 Apr;3(2):75-81. Epub 2012 Aug 9.

Local application of hyaluronan gel in conjunction with periodontal surgery: a randomized controlled trial. Fawzy El-Sayed KM, Dahaba MA, Aboul-Ela S, Darhous MS. – Clin Oral Investig. 2012 Aug;16(4):1229-36. doi: 10.1007/s00784-011-0630-z. Epub 2011 Oct 20.

Comparative analysis of hyaluronan gel and xanthan-based chlorhexidine gel, as adjunct to scaling and root planing with scaling and root planing alone in the treatment of chronic periodontitis: A preliminary study. Chauhan AS, Bains VK, Gupta V, Singh GP, Patil SS. – Contemp Clin Dent. 2013 Jan;4(1):54-61. doi: 10.4103/0976-237X.111619.

Treatment of infrabony periodontal defects using a resorbable biopolymer of hyaluronic acid: a randomized clinical trial. Briguglio F, Briguglio E, Briguglio R, Cafiero C, Isola G. – Quintessence Int. 2013 Mar;44(3):231-40. doi: 10.3290/j.qi.a29054.

Hyaluronic Acid as an adjunct to scaling and root planing in chronic periodontitis. A randomized clinical trail. Rajan P, Baramappa R, Rao NM, Pavaluri AK, P I, Rahaman SM. – J Clin Diagn Res. 2014 Dec;8(12):ZC11-4. doi: 10.7860/JCDR/2014/8848.5237. Epub 2014 Dec 5.

Oral soft tissue wound healing after laser surgery with or without a pool of amino acids and sodium hyaluronate: a randomized clinical study. Romeo U, Libotte F, Palaia G, Galanakis A, Gaimari G, Tenore G, Del Vecchio A, Polimeni A. – Photomed Laser Surg. 2014 Jan;32(1):10-6. doi: 10.1089/pho.2013.3509. Epub 2013 Dec 14.

Efficacy of hyaluronic acid (hyaluronan) in root coverage procedures as an adjunct to coronally advanced flap in Millers Class I recession: A clinical study. Kumar R, Srinivas M, Pai J, Suragimath G, Prasad K, Polepalle T. – J Indian Soc Periodontol. 2014 Nov-Dec;18(6):746-50. doi: 10.4103/0972-124X.147411.

Local delivery of hyaluronan 0.8% as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinical and microbiological study. Polepalle T, Srinivas M, Swamy N, Aluru S, Chakrapani S, Chowdary BA. – J Indian Soc Periodontol. 2015 Jan-Feb;19(1):37-42. doi: 10.4103/0972-124X.145807.


Antiproliferative effect of topic hyaluronic acid gel. Study in gingival biopsies of patients with periodontal disease. Mesa FL, Aneiros J, Cabrera A, Bravo M, Caballero T, Revelles F, del Moral RG, O’Valle F. – Histol Histopathol. 2002;17(3):747-53.

Clinical and microbiological effects of topical subgingival application of hyaluronic acid gel adjunctive to scaling and root planing in the treatment of chronic periodontitis. Xu Y, Höfling K, Fimmers R, Frentzen M, Jervøe-Storm PM. – J Periodontol. 2004 Aug;75(8):1114-8.

Clinical study of hyaluronic acid in the treatment of chronic periodontitis]. Xu Y, Frentzen M, Jerve- Storm PM. – Hua Xi Kou Qiang Yi Xue Za Zhi. 2004 Feb;22(1):32-4. Chinese.

Local delivery of hyaluronan as an adjunct to scaling and root planing in the treatment of chronic periodontitis. – Johannsen A, Tellefsen M, Wikesjö U, Johannsen G. -J Periodontol. 2009 Sep;80(9):1493-7. doi: 10.1902/jop.2009.090128.

Hyaluronic Acid: a boon in periodontal therapy. Dahiya P, Kamal R. – N Am J Med Sci. 2013 May;5(5):309-15. doi: 10.4103/1947 – 2714.112473. Sahayata VN, Bhavsar NV, Brahmbhatt NA.

An evaluation of 0.2% hyaluronic acid gel (Gengigel ®) in the treatment of gingivitis: a clinical & microbiological study. Oral Health Dent Manag. 2014 Sep;13(3):779-85.


Peri-implant maintenance of immediate function implants: a pilot study comparing hyaluronic acid and chlorhexidine. de Araújo Nobre M, Cintra N, Maló P. – Int J Dent Hyg. 2007 May;5(2):87-94.

Treatment of infrabony periodontal defects with esterified hyaluronic acid: clinical report of 19 consecutive lesions. Vanden Bogaerde L. – Int J Periodontics Restorative Dent. 2009 Jun;29(3):315-23.

Esterified hyaluronic acid and autologous bone in the surgical correction of the infra-bone defects. Ballini A, Cantore S, Capodiferro S, Grassi FR. – Int J Med Sci. 2009;6(2):65-71. Epub 2009 Feb 26.

Efficacy of hyaluronic acid spray on swelling, pain, and trismus after surgical extraction of impacted mandibular third molars. Koray M, Ofluoglu D, Onal EA, Ozgul M, Ersev H, Yaltirik M, Tanyeri H. – Int J Oral Maxillofac Surg. 2014 Nov;43(11):1399-403. doi: 10.1016/j.ijom.2014.05.003. Epub 2014 Jun 10.


The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. Nolan A, Baillie C, Badminton J, Rudralingham M, Seymour RA. – J Oral Pathol Med. 2006 Sep;35(8):461-5.

The efficacy of topical 0.2% hyaluronic acid gel on recurrent oral ulcers: comparison between recurrent aphthous ulcers and the oral ulcers of Behçet’s disease. Lee JH, Jung JY, Bang D. – J Eur Acad Dermatol Venereol. 2008 May;22(5):590-5. Epub 2007 Dec 17.


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